Peter Schlenke is director of the clinical department of blood group serology and transfusion medicine and group leader of the research unit „Hematopoietic stem cell differentiation“. The research activities aim to better understand the molecular mechanisms to instruct multipotent hematopoietic stem cells into lineage-committed progenitors and mature blood cells.
Our team has international expertise especially on in-vitro generation of already enucleated reticulocytes in three-phase liquid cultures. Experiments are currently underway to scale up the expansion of red blood cells and to improve the final maturation including the enucleation process and the cytoskeletal remodelling into biconcave erythrocytes. The experimental data obtained serves as basis to translate these findings into a concept of biotechnological manufacturing of carefully phenotyped red blood cells under consideration of the requirements of Good Manufacturing Practices (GMP). In parallel, we will extend our research efforts to the adjacent fields of myelopoiesis and megakaryopoiesis as well as to hematopoiesis-associated disease models such as sickle cell disease.
Letzte Aktualisierung: 06.03.2015